Triggering myelopoiesis

Cdc42 Critically Regulates the Balance Between Myelopoiesis and Erythropoiesis Running title: Cdc42 in myelopoiesis and erythropoiesis

Panax ginseng Modulates Cytokines in Bone Marrow Toxicity and Myelopoiesis: Ginsenoside Rg1 Partially Supports Myelopoiesis

In this study, we have demonstrated that Korean Panax ginseng (KG) significantly enhances myelopoiesis in vitro and reconstitutes bone marrow after 5-flurouracil-induced (5FU) myelosuppression in mice. KG promoted total white blood cell, lymphocyte, neutrophil and platelet counts and improved body weight, spleen weight, and thymus weight. The number of CFU-GM in bone marrow cells of mice and se...

MDSCs and TAMs result from altered myelopoiesis

Tumor progression depends on the gradual accumulation of genetic and epigenetic aberrations in cancer cells that also modify the cellular composition of the tumor environment, establishing a state of chronic inflammation characterized by the stromal infiltration of immune cells. Myeloid cells play a critical role in sustaining cancer progression (1). Moreover, inflammatory myeloid cells help to...

Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish

Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements in our capacity to identify, isolate, and culture such haematopoietic cells continue to enhance our ability to use this simple organism to address...

13-P017 Live imaging demand-driven myelopoiesis

ulate the transition between self-renewal and differentiation stage in different systems, and both are associated with the maintenance of the progenitor state. The general question that arises is how those signals are integrated within otic progenitors so that they result in a precise cell diversification. We have studied the interactions between Sox2 and Notch pathways in otic neurosensory pro...